Pathogenesis of Graves’ Ophthalmopathy
نویسندگان
چکیده
منابع مشابه
The pathogenesis and treatment of Graves' ophthalmopathy.
Graves' ophthalmopathy (GO) is probably an autoimmune condition although the pathogenesis is still not fully understood. GO is frequently, though not invariably, associated with Graves' disease and it may in fact be a separate disease entity. Ophthalmopathy is commonest in the 30 to 50 age group",2'3 and is more common in women (2:1, female:male), although the female preponderance is not so mar...
متن کاملGraves’ Ophthalmopathy
Copyright © 2009 Massachusetts Medical Society. A 40-year-old woman who recently received a diagnosis of Graves’ disease comes for a follow-up visit. She has been taking methimazole, at a dose of 10 mg daily, and is now euthyroid, but for the past 3 months, she has had bothersome eye symptoms, including redness, tearing, grittiness, photophobia, diplopia at the extremes of gaze, and ocular pain...
متن کاملCurrent Insights into the Pathogenesis of Graves' Ophthalmopathy.
Environmental, genetic, and immune factors are at play in the development of the variable clinical manifestations of Graves' ophthalmopathy (GO). Among the environmental contributions, smoking is the risk factor most consistently linked to the development or worsening of the disease. The close temporal relationship between the diagnoses of Graves' hyperthyroidism and GO have long suggested that...
متن کاملTSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis.
CONTEXT The TSH receptor (TSHR) is considered the main target of stimulatory autoantibodies in the pathogenesis of Graves' ophthalmopathy (GO); however, it has been suggested that stimulatory IGF-1 receptor (IGF-1R) autoantibodies also play a role. OBJECTIVE We previously demonstrated that a monoclonal stimulatory TSHR antibody, M22, activates TSHR/IGF-1R cross talk in orbital fibroblasts/pre...
متن کاملPreventing Graves' Ophthalmopathy
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 1997
ISSN: 1018-2438,1423-0097
DOI: 10.1159/000237652